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The SAGE Handbook of Health Psychology - Page 302
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integrated biomarker response of human Centre Research
integrated biomarker response of human SAGE Handbook of Health psychology
Daliah Ross, MA (@daliahross) / X
un exemple concret d’utilisation de l’IBR (Integrated Biomarker Responses) en recherche sur les humains.
Une étude a été menée pour améliorer la prédiction de la réponse aux médicaments en utilisant une intégration d’apprentissage machine multi-modale et -omique, appelée MOMLIN1. Cette étude a été réalisée sur des données cliniques de patients atteints de cancer du sein1.
MOMLIN utilise conjointement des algorithmes de corrélation sparse et des algorithmes de sélection de caractéristiques spécifiques à la classe, qui identifient des composants interprétables associés à plusieurs modalités et -omiques1.
MOMLIN a été appliqué à des ensembles de données de cancer du sein de 147 patients (données cliniques, mutations, expression génique, cellules de microenvironnement tumoral et voies moléculaires) pour analyser les prédictions de classes de réponse aux médicaments pour les non-répondeurs et les répondeurs variables1.
Par exemple, une interaction entre ER-négatif-HMCN1-COL5A1 mutations-FBXO2-CSF3R expression-CD8 émerge comme un biomarqueur multimodal pour les répondeurs, affectant potentiellement les peptides antimicrobiens et les voies de signalisation FLT31. En revanche, pour les cas de résistance, une combinaison distincte de lymph node-TP53 mutation-PON3-ENSG00000261116 lncRNA expression-HLA-E-T-cell exclusions a émergé comme des biomarqueurs multimodaux1.
Cet exemple illustre comment l’IBR peut être utilisé pour évaluer l’impact de la pollution sur la faune aquatique et aider à identifier les zones les plus touchées par la pollution1.
Existe-t-il d'autres exemples de recherche sur les humains qui ont utilisé l'IBR?
Envoyé par vous : Existe-t-il d'autres exemples de recherche sur les humains qui ont utilisé l'IBR?
Oui, il existe d’autres exemples de recherche sur les humains qui ont utilisé l’IBR (Integrated Biomarker Responses).
L’IBR (Integrated Biomarker Response) est généralement utilisé dans les études environnementales, en particulier pour évaluer l’impact de la pollution sur les organismes non humains comme les poissons et les mollusques.
Cependant, les principes de l’IBR peuvent être appliqués à la recherche sur les humains, en particulier dans le domaine de la médecine personnalisée. Par exemple, une variété de biomarqueurs - y compris les marqueurs génétiques, protéomiques et métabolomiques - peuvent être utilisés pour évaluer la réponse d’un individu à un traitement médical. Ces biomarqueurs peuvent ensuite être intégrés à l’aide d’une approche similaire à l’IBR pour obtenir une vue d’ensemble de la réponse du patient.
Cependant, je tiens à préciser que l’utilisation de l’IBR dans la recherche sur les humains est encore un domaine émergent et que davantage de recherches sont nécessaires pour établir son utilité et sa validite
intégrées aux biomarqueurs (Integrated Biomarker Responses, IBR) semble prometteur. Les chercheurs ont développé des indices tels que les réponses intégrées aux biomarqueurs (IBR) et la version 2 de la réponse intégrée aux biomarqueurs (IBRv2) pour résumer toutes les réponses des biomarqueurs en une seule valeur1. Cependant, ces indices ne préservent pas la variabilité biologique originale, ce qui entrave les analyses statistiques ultérieures1.
Pour résoudre ce problème, de nouvelles versions de l’IBR et de l’IBRv2 ont été créées, qui préservent la variabilité des données individuelles et peuvent être utilisées dans des analyses statistiques typiques. Ce sont les indices de réponses intégrées aux biomarqueurs individuels (IBRi), la version 2 individuelle des réponses intégrées aux biomarqueurs (IBRv2i), et la version 2 individuelle des réponses intégrées aux biomarqueurs pondérées (Weighted IBRv2i)1.
Ces indices sont avantageux car ils maintiennent la variabilité des données des groupes expérimentaux et peuvent être analysés à l’aide de statistiques de test d’hypothèse comme tout autre paramètre1. Cette approche peut aider à traduire le langage scientifique technique en un langage plus accessible, adapté aux agences gouvernementales environnementales et aux décideurs1.
En résumé, l’avenir de l’IBR semble se diriger vers des versions améliorées de l’indice qui préservent la variabilité des données, permettant ainsi des analyses statistiques plus robustes et une communication plus efficace des résultats aux parties prenantes1.
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Israel-Gaza on brink of war; IAF strikes PIJ
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Could Israel have prevented Hamas' October 7th attack? Katie Couric New 18K ... LIVE: Putin Hosts Iran's President Raisi In Moscow Amid Israel-Hamas War | Ukraine ...
Attack on Iran Shiite shrine leaves one dead: state media
https://www.arabnews.com › node
13 août 2023 — The war in Gaza was triggered by Hamas's October 7 attack on Israel, which ... coordination among the bloc received wide support during the organization's talks ...
Russian Lifting Of Visas, Flight Ban Highlight Georgia's ...
https://www.rferl.org › georgia-rus...
11 mai 2023 — ... Hamas after a Hamas attack killed at least 1,200 people in Israel, most of them civilians. Iran-backed Huthi rebels in Yemen have also waged attacks on ...
Russia-Ukraine War: What Happened When Explosions ...
https://www.nytimes.com › live › 2023/05/03 › world
3 mai 2023 — ... attacks on Russia or Russian-occupied territory. They include last August's car bombing outside Moscow that killed Daria Dugina, the daughter of a leading ...
Serbs Hand In More Than 100000 Illegal Weapons ...
https://www.rferl.org › serbia-illega...
2 juil. 2023 — ... attack on October 7 attack. (file photo). Israel's government said on ... Hamas attack killed at least 1,200 people in Israel, most of them civilians. The ...
Ramaphosa's “Peace Initiative” with Ukraine is organized by a ...
https://nationalsecuritynews.com › ...
19 juin 2023 — ... Hamas' brutal attacks. October 24, 2023. Hamas claims two hostages rejected by Israel: The Unresolved Fate of Nurit Yitzhak and Yocheved Lifshitz. October 23, ...
Fire At Military Base In Crimea Forces Evacuations ...
https://www.rferl.org › crimea-fire-...
19 juil. 2023 — U.S. forces in Iraq and Syria have reportedly come under attack more than 165 times since October 7. Most of the attacks have been claimed by the so-called ...
Russia targets Ukraine's farm storage sites after days of ...
https://www.lemonde.fr › article
22 juil. 2023 — ... attack in Odesa region, Ukraine, Friday, July 21, 2023. LIBKOS / AP. Russia targeted ... Attacks in recent days have put Odesa in Russia's crosshairs after Moscow ...
Desperate Ukrainians take long and uncertain journey to ...
https://www.ctvnews.ca › world
11 juil. 2023 — Russia says it foiled Ukrainian drone attack on Moscow as Kyiv's counteroffensive grinds on ... Hamas attack last October. Now, global affairs experts are worried ...
Ukraine Says It Retook Two Villages As Counteroffensive ...
https://www.rferl.org › ukraine-hea...
11 juin 2023 — ... Some 72,000 Palestinian workers were employed on construction sites in Israel prior to the attack on October 7 attack. (file photo). Israel's ...
Deadly Russian strike hits blood transfusion centre, says ...
https://www.france24.com › europe
5 août 2023 — ... attack, citing the Maritime Rescue Coordination Centre of Novorossiysk. Traffic on the bridge across the Kerch Strait linking the Moscow-annexed Crimean ...
Moscow's Domodedovo, Vnukovo airports suspend flight ...
19 août 2023 — Yemen's Houthis claim missile attack on Israel's Eilat · 12:10. Armenia sees ... MOSCOW, August 20. /TASS/. Moscow's Domodedovo and Vnukovo airports have ...
With More Strikes in Russia, Ukraine Makes Calculation ...
https://www.nytimes.com › live › 2022/12/26 › world
3 mai 2023 — Attacks inside Russia potentially complicate Moscow's campaign of striking Ukraine's energy grid. ... October: A sea drone attack in Crimea. Russia accused ...
US announces additional $400 million security aid ...
https://www.france24.com › europe
25 juil. 2023 — The reported attack comes a day after Russia warned of "tough retaliatory measures" after a drone attack on Moscow, some 500 kilometres (300 miles) from Ukraine ...
Moscow 'dissatisfied' with Armenian prime minister's ...
4 sept. 2023 — Timeframes for Maduro's visit to Russia currently being coordinated, Russian envoy says ... October 7, 2023 attack by Hamas. Read more · Now. Polet can make up to ...
Alert 2023! Report on conflicts, human rights and ...
https://www.un.org › uploads › 2023/07 › alert2023
27 juil. 2023 — in pursuit of easy targets, such as the October attacks in. Mogadishu that caused ... the biggest coordinated attack in southern Thailand in recent years, the ...
Highest-Ever Number of Violations against Children Verified ...
https://press.un.org › sc15343.doc....
5 juil. 2023 — However, the main perpetrators of the killing and maiming of children, attacks on schools and hospitals and denial of humanitarian access in 2022 were the armed ...
Saudi-Russia Oil Curbs Signal a Special Relationship
https://www.bloomberg.com › news
4 juil. 2023 — The two nations coordinate cuts even though Moscow ... US military bases scattered across Iraq and Syria had come under attack more than 160 times since Hamas's ...
Six-Day War
https://en.wikipedia.org › wiki › Si...
12 avr. 2023 — Another was destroyed by an exploding Egyptian bomber. The attack guaranteed Israeli air supremacy for the rest of the war. Attacks on other Arab air forces by ...
What does Russia think it will take to end the war with ...
https://www.arabnews.com › world
31 juil. 2023 — ... Moscow in response to the Ukraine invasion. On the ... He said none of this was justified, despite the attack by Hamas that killed 1,200 Israelis on October 7.
Moscow Says It Shot Down Two Ukrainian Missiles Over ...
https://www.rferl.org › russia-rosto...
28 juil. 2023 — ... Hamas attack killed at least 1,200 people in Israel, most of them civilians. The Iran-backed Huthi rebels hit in Yemen on February 3 have also waged attacks ...
Tbilisi LGBT Event Forced To Cancel After Far-Right ...
https://www.rferl.org › georgia-lgb...
8 juil. 2023 — ... Some 72,000 Palestinian workers were employed on construction sites in Israel prior to the attack on October 7 attack. (file photo). Israel's ...
Putin says he won't renew the grain deal until the West ...
4 sept. 2023 — ... Moscow's demands on its own agricultural exports ... Jordan attack attribution · Alec Baldwin · Barcelona beat Osasuna · World News ...
CrisisWatch: June Alerts and May Trends 2023
https://www.crisisgroup.org › crisiswatch › june-alerts-an...
18 juin 2023 — Amid fragile M23 calm, other armed group attacks continued unabated in east. Local CMC-Nyatura militia 3-4 May killed 13 people in attack on Kizimba site for ...
Deadly Russian strike on hospital, Kremlin talks with China ...
https://www.france24.com › europe
26 mai 2023 — A hospital in the eastern Ukrainian city of Dnipro was hit Friday morning in a Russian missile attack, regional governor Serhiy Lysak said ... Moscow for its ...
US sending F-16 fighter jets to protect ships from Iranian ...
https://www.arabnews.pk › node
15 juil. 2023 — ... 10 attack aircraft that have been patrolling there for more than a week. The ... Hamas following the Oct. 7 attack on Israel. The war has led to the deaths ...
Israeli warplanes target Syrian air defense battery
https://www.arabnews.com › node
2 juil. 2023 — “Moscow and Tehran are working more closely together but their relationship may be ... Hamas in response to the October attack. Netanyahu has also opposed ...
Moscow's Mayor Says Drones Targeted Russian Capital
https://www.nytimes.com › world › russia-ukraine-news
5 juil. 2023 — All the drones were shot down in what appeared to be the first such attack in months. Russia blamed Ukraine, but Kyiv denied involvement.
El-Sisi reiterates Egypt's firm position in support of the ...
https://www.arabnews.com › node
31 juil. 2023 — Since the outbreak of war between Hamas and Israel on October 7, the border ... After the Oct. 7 attack, the war in Gaza had broad domestic support, even if ...
Israel strikes Gaza killing 13 people, including four children
https://www.aljazeera.com › news
8 mai 2023 — Hamas chief Ismail Haniyeh said in a statement that ... Israel's army claims the men were involved in a shooting attack in which an Israeli civilian was wounded.
Wagner Chief Threatens To Pull Out Of Bakhmut As ...
https://www.rferl.org › ukraine-zel...
29 avr. 2023 — ... Some 72,000 Palestinian workers were employed on construction sites in Israel prior to the attack on October 7 attack. (file photo). Israel's ...
Russian strikes kill 13 fighters in Syria rebel area: monitor
https://www.arabnews.com › node
22 août 2023 — 7 attack by Hamas militants, in contrast to several other countries. Asked ... Since the outbreak of war between Hamas and Israel on October 7, the border ...
The Diplomatic Challenge: Discouraging UAE's Trade with ...
https://tacticsinstitute.com › europe
5 sept. 2023 — ... Hamas · January 8, 2024 · Analyzing Israel's Intelligence Failure to Counter Hamas Aggression · January 6, 2024 · Oct 7 Hamas Attack: Assessing IDF ...
Ukraine from June 26 to July 21: Belarus forces hold ...
https://asia.nikkei.com › Ukraine-war
20 juil. 2023 — "We believe that this is a coordinated effort to justify any attacks ... Russian accounts of the front line say Moscow's forces repelled Ukrainian attacks near ...
Putin Tells Poland Any Aggression Against Belarus Is ...
https://www.rferl.org › belarus-wag...
21 juil. 2023 — ... Moscow's neighbor and close ally Belarus would be considered an attack on Russia. ... attack more than 165 times since October 7. Most of the attacks have been ...
European Strategic Intelligence and Security Center: ESISC
17 juin 2023 — ... HAMAS. 19/10/2023 - 10:42. Une explosion a touché, mardi soir, l'hôpital Ahli Arab de ... Hamas attack was being planned? According to an Egyptian intelligence ...
Wagner Boss Confirms Cancellation of Advance on Moscow
https://www.farsnews.ir › news
25 juin 2023 — The talks were held in coordination with Russian President ... Survey Finds Most Arabs View Hamas's October 7 Attack as 'Legitimate Resistance Operation'.
The Panama Papers: Exposing the Rogue Offshore ...
https://www.icij.org › investigations
13 juil. 2023 — IMPACT. Woman stands at a podium that reads fincen.gov/boi, in front of · Jan 17, 2024. New US company ownership database faces continued political attacks ...
Wagner Chief Refuses To Obey Decree In Latest Spat ...
https://www.rferl.org › russia-prigo...
11 juin 2023 — Washington's Allies Warn Iran And 'Proxies' After U.S. Strikes On Militia Targets In Iraq, Syria; Tehran 'Strongly' Condemns Attacks. U.S. President ...
Russian raid off Turkey's coast tests Erdogan's resolve
https://www.reuters.com › world
16 août 2023 — ... Moscow back to a grain-export deal that would restore some calm to the Black ... attack, source says. 16 hours ago. A general view shows the oil refinery of ...
Russian Tourists Visiting Occupied Crimea Drop By Nearly ...
https://www.rferl.org › russia-ukrai...
6 août 2023 — The number of Russians vacationing in Crimea, the Ukrainian Black Sea peninsula occupied by Moscow ... Hamas's attack on Israel on October 7. At least 1,200 ...
CrisisWatch: August Alerts and July Trends 2023
https://www.crisisgroup.org › crisiswatch › august-alerts-...
2 août 2023 — Troops 20 July also repelled ISWAP attack on army post near Monguno town. Jihadist attacks continued, however. Jihadist activity reported in North West zone ...
Poland reaches agreement on transit of Ukrainian grain
https://www.france24.com › europe
18 avr. 2023 — 4:35 am: Russian drones hit Odesa causing a fire, says Ukranian official. Russia launched a drone attack on Ukraine's southern port city of Odesa early ...
'World must act against rising Israeli-settler violence on ...
https://www.arabnews.com › node
15 juin 2023 — Oslo is maintaining its funding following accusations that some agency staff took part in the Oct. 7 attack by Hamas militants, in contrast to several other ...
'Cost Of War': Czech President Says Russians In West ...
https://www.rferl.org › czech-presi...
15 juin 2023 — ... Hamas attack killed at least 1,200 people in Israel, most of them civilians. The Iran-backed Huthi rebels hit in Yemen on February 3 have also waged attacks ...
Russian Comedian Who Opposes Ukraine War Says ...
https://www.rferl.org › russia-come...
31 août 2023 — Meanwhile, Russian air defenses repelled a Ukrainian drone attack on January 29 on the Slavneft-YANOS oil refinery in the city of Yaroslavl, northeast of Moscow ...
il y a 23 minutes — Russia promotes S-400 ADS in Middle East. Real combat in Ukraine confirmed that the complex can down both aerodynamic and ballistic missiles. RIYADH, February 5 ...
Termes manquants : coordinated | Afficher les résultats avec : coordinated
Western sanctions fail to bar Russian arms trade
il y a 26 minutes — Russia says two Ukrainian soldiers surrendered in Krasny Liman area. The ... Russian air defense repels Ukraine's attack on settlement in Zaporozhye Region.
Termes manquants : coordinated | Afficher les résultats avec : coordinated
World News
https://www.wsls.com › news › world
il y a 5 minutes — Paris police say suspect in train station attack that injured 3 may have mental health issues ... The U.S. military has launched an air assault on dozens of ...
Pakistan court finds ex-PM Imran Khan's marriage illegal
https://www.arabnews.pk › world
il y a 22 minutes — It is the third verdict in a week to attack the former international cricket star's reputation, after he was given concurrent prison sentences of 10 years for ...
French humanitarian workers killed in Ukraine: Russian ...
https://newsrnd.com › news › 2024...
il y a 10 minutes — War in Ukraine: who are the two French humanitarian workers killed in a Russian strike? ... Latest. Losses for Russia: Moscow loses 810 soldiers in just one day 2 ...
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https://newsrnd.com › news › 2024...
il y a 44 minutes — This follows the death of two French humanitarian workers in the Kherson region (Ukraine) after a Russian strike this Friday. ... coordinated maneuver by Russia” ...
il y a 25 minutes — US coordinated Attacks in Iraq with ISIS Terrorists who... INVESTIGATIONS · Kharkov: Two Ukrainian Battalions Crushed in Moonshine Ploy:
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