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The SAGE Handbook of Health Psychology - Page 302
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integrated biomarker response of human Centre Research
integrated biomarker response of human SAGE Handbook of Health psychology
Daliah Ross, MA (@daliahross) / X
un exemple concret d’utilisation de l’IBR (Integrated Biomarker Responses) en recherche sur les humains.
Une étude a été menée pour améliorer la prédiction de la réponse aux médicaments en utilisant une intégration d’apprentissage machine multi-modale et -omique, appelée MOMLIN1. Cette étude a été réalisée sur des données cliniques de patients atteints de cancer du sein1.
MOMLIN utilise conjointement des algorithmes de corrélation sparse et des algorithmes de sélection de caractéristiques spécifiques à la classe, qui identifient des composants interprétables associés à plusieurs modalités et -omiques1.
MOMLIN a été appliqué à des ensembles de données de cancer du sein de 147 patients (données cliniques, mutations, expression génique, cellules de microenvironnement tumoral et voies moléculaires) pour analyser les prédictions de classes de réponse aux médicaments pour les non-répondeurs et les répondeurs variables1.
Par exemple, une interaction entre ER-négatif-HMCN1-COL5A1 mutations-FBXO2-CSF3R expression-CD8 émerge comme un biomarqueur multimodal pour les répondeurs, affectant potentiellement les peptides antimicrobiens et les voies de signalisation FLT31. En revanche, pour les cas de résistance, une combinaison distincte de lymph node-TP53 mutation-PON3-ENSG00000261116 lncRNA expression-HLA-E-T-cell exclusions a émergé comme des biomarqueurs multimodaux1.
Cet exemple illustre comment l’IBR peut être utilisé pour évaluer l’impact de la pollution sur la faune aquatique et aider à identifier les zones les plus touchées par la pollution1.
Existe-t-il d'autres exemples de recherche sur les humains qui ont utilisé l'IBR?
Envoyé par vous : Existe-t-il d'autres exemples de recherche sur les humains qui ont utilisé l'IBR?
Oui, il existe d’autres exemples de recherche sur les humains qui ont utilisé l’IBR (Integrated Biomarker Responses).
L’IBR (Integrated Biomarker Response) est généralement utilisé dans les études environnementales, en particulier pour évaluer l’impact de la pollution sur les organismes non humains comme les poissons et les mollusques.
Cependant, les principes de l’IBR peuvent être appliqués à la recherche sur les humains, en particulier dans le domaine de la médecine personnalisée. Par exemple, une variété de biomarqueurs - y compris les marqueurs génétiques, protéomiques et métabolomiques - peuvent être utilisés pour évaluer la réponse d’un individu à un traitement médical. Ces biomarqueurs peuvent ensuite être intégrés à l’aide d’une approche similaire à l’IBR pour obtenir une vue d’ensemble de la réponse du patient.
Cependant, je tiens à préciser que l’utilisation de l’IBR dans la recherche sur les humains est encore un domaine émergent et que davantage de recherches sont nécessaires pour établir son utilité et sa validite
intégrées aux biomarqueurs (Integrated Biomarker Responses, IBR) semble prometteur. Les chercheurs ont développé des indices tels que les réponses intégrées aux biomarqueurs (IBR) et la version 2 de la réponse intégrée aux biomarqueurs (IBRv2) pour résumer toutes les réponses des biomarqueurs en une seule valeur1. Cependant, ces indices ne préservent pas la variabilité biologique originale, ce qui entrave les analyses statistiques ultérieures1.
Pour résoudre ce problème, de nouvelles versions de l’IBR et de l’IBRv2 ont été créées, qui préservent la variabilité des données individuelles et peuvent être utilisées dans des analyses statistiques typiques. Ce sont les indices de réponses intégrées aux biomarqueurs individuels (IBRi), la version 2 individuelle des réponses intégrées aux biomarqueurs (IBRv2i), et la version 2 individuelle des réponses intégrées aux biomarqueurs pondérées (Weighted IBRv2i)1.
Ces indices sont avantageux car ils maintiennent la variabilité des données des groupes expérimentaux et peuvent être analysés à l’aide de statistiques de test d’hypothèse comme tout autre paramètre1. Cette approche peut aider à traduire le langage scientifique technique en un langage plus accessible, adapté aux agences gouvernementales environnementales et aux décideurs1.
En résumé, l’avenir de l’IBR semble se diriger vers des versions améliorées de l’indice qui préservent la variabilité des données, permettant ainsi des analyses statistiques plus robustes et une communication plus efficace des résultats aux parties prenantes1.
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Could Israel have prevented Hamas' October 7th attack? Katie Couric New 18K ... LIVE: Putin Hosts Iran's President Raisi In Moscow Amid Israel-Hamas War | Ukraine ...
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